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KMID : 1161420110140101159
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Journal of Medicinal Food
2011 Volume.14 No. 10 p.1159 ~ p.1166
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Morinda citrifolia Linn Leaf Extract Possesses Antioxidant Activities and Reduces Nociceptive Behavior and Leukocyte Migration
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Serafini Mairim Russo
Santos Rodrigo Correia
Guimaraes Adriana Gibara
dos Santos Joao Paulo Almeida
da Conceicao Santos Alan Diego
Alves Izabel Almeida
Gelain Daniel Pens
de Lima Nogueira Paulo Cesar
Quintans-Junior Lucindo Jose
Bonjardim Leonardo Rigoldi
de Souza Araujo Adriano Antunes
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Abstract
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Herbal drugs have been used since ancient times to treat a wide range of diseases. Morinda citrifolia Linn (popularly known as “Noni”) has been used in folk medicine by Polynesians for over 2,000 years. It is reported to have a broad range of therapeutic effects, including effects against headache, fever, arthritis, gingivitis, respiratory disorders, infections, tuberculosis, and diabetes. The aim of this study was to investigate the antioxidant, anti-inflammatory, antinociceptive, and antibacterial properties of the aqueous extract from M. citrifolia leaves (AEMC). Antioxidant activity was observed against lipid peroxidation, nitric oxide, and hydroxyl radicals. The antinociceptive effect of AEMC was observed in the acetic acid?induced writhing test at the higher dose. Moreover, AEMC significantly reduced the leukocyte migration in doses of 200 and 400?mg/kg and showed mild antibacterial activity. Together, the results suggest that properties of M. citrifolia leaf extract should be explored further in order to achieve newer tools for managing painful and inflammation conditions, including those related to oxidant states.
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KEYWORD
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anti-inflammatory activity, antinociceptive activity, antioxidant activity, Morinda citrifolia
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